GTX61425-产品快照
- 品牌:
- GTX61425
- 型号:
- GTX61425
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产品介绍
GTX61425
Genetex - GTX61425 - NGF Receptor antibody [EP1039Y] (Each (100µl))
GTX61425
Neurotrophins signal cell survival, differentiation, growth cessation, and apoptosis through two classes of cell surface receptors, the Trks and NGF Receptor (p75NTR). p75NTR, when activated in the absence of a strong Trk signal, induces apoptosis of neurons, while in the presence of Trk it enhances responses to neurotrophin . p75NTR, when it is not bound by NGF, may play a role in neuronal selection during embryonic development and suggest that neuroblastomas may arise from immature neuroblasts that escape programmed cell death. Therefore, the loss of p75NTR expression in developing neural crest cells might be a primary event in the genesis of neuroblastoma . It has also been suggested that neuronal death in Alzheimer's disease is mediated, at least in part, by the interaction of beta-amyloid with p75NTR, and suggest new targets for therapeutic intervention . This listing is for Each (100µl) See other products in some related categories (click to browse): Industrial & Scientific > Laboratory & Science Antigen NGF Receptor Host Rabbit Reactivity Human, Mouse, Rat Clone EP1039Y Isotype IgG Molecular Weight 75 kDa Unit Each (100µl) Application Note Recommended Starting Dilutions: For WB: Use at a dilution of 1:1, 000-10, 000 For IHC: Use at a dilution of 1:50 100 For ICC: Use at a dilution of 1:50 For IP: Use at a dilution of 1:50 Optimal working dilution for a specific application should be determined by the investigator. ChIP No ELISA No Flow Cytometry No Gel Shift No Immunochemistry Yes Immunofluorescence Yes Immunogen A synthetic peptide corresponding to residues of human NGFR was used as an immunogen. Immunoprecipitation Yes Monoclonal/Polyclonal Monoclonal Neutralization No Purification Cell Supernatant Storage Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Storage Instruction Store at -20 °C. Stable for 12 months from date of receipt. Tested Applications ICC/IF, IHC-P, IHC-M, IP, WB Type Primary Western Blot Yes
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